This time we are looking on the crossword clue for: “Gee whiz!”.
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Possible Answers: EGAD, OOH, MAN, BOY, GOSH, OHWOW, GOLLY, MANALIVE, FORGOODNESSSAKE.
Random information on the term “EGAD”:
Glutamate decarboxylase or glutamic acid decarboxylase (GAD) is an enzyme that catalyzes the decarboxylation of glutamate to GABA and CO2. GAD uses PLP as a cofactor. The reaction proceeds as follows:
In mammals, GAD exists in two isoforms encoded by two different genes – GAD1 and GAD2. These isoforms are GAD67 and GAD65 with molecular weights of 67 and 65 kDa, respectively. GAD1 and GAD2 are expressed in the brain where GABA is used as a neurotransmitter, GAD2 is also expressed in the pancreas.
At least two more forms, GAD25 and GAD44 (embryonic; EGAD) are described in the developing brain. They are coded by the alternative transcripts of GAD1, I-80 and I-86: GAD25 is coded by both, GAD44 – only by I-80.
GAD65 and GAD67 synthesize GABA at different locations in the cell, at different developmental times, and for functionally different purposes. GAD67 is spread evenly throughout the cell while GAD65 is localized to nerve terminals. This difference is thought to reflect a functional difference; GAD67 synthesizes GABA for neuron activity unrelated to neurotransmission, such as synaptogenesis and protection from neural injury. This function requires widespread, ubiquitous presence of GABA. GAD65, however, synthesizes GABA for neurotransmission, and therefore is only necessary at nerve terminals and synapses. In order to aid in neurotransmission, GAD65 forms a complex with Heat Shock Cognate 70 (HSC70), cysteine string protein (CSP) and Vesicular GABA transporter VGAT, which, as a complex, helps package GABA into vesicles for release during neurotransmission. GAD67 is transcribed during early development, while GAD65 is not transcribed until later in life. This developmental difference in GAD67 and GAD65 reflects the functional properties of each isoform; GAD67 is needed throughout development for normal cellular functioning, while GAD65 is not needed until slightly later in development when synaptic inhibition is more prevalent.
Random information on the term “OOH”:
Out-of-home media advertising (also OOH advertising or outdoor advertising) or out-of-home media (also OOH media or outdoor media) is advertising that reaches the consumers while they are outside their homes.
Out-of-home media advertising is focused on marketing to consumers when they are “on the go” in public places, in transit, waiting (such as in a medical office), and/or in specific commercial locations (such as in a retail venue). OOH advertising formats fall into six main categories: billboards, street, roads, highways, transit, and alternative.
The OOH advertising industry in the United States includes more than 2,100 operators in 50 states representing the major out of home format categories. These OOH media companies range from public, multinational media corporations to small, independent, family-owned businesses. Currently, the United Kingdom and France are Western Europe’s first and second largest markets for OOH, respectively. Data from Outsmart (formerly the Outdoor Media Centre), the UK’s out-of-home advertising trade association, shows that DOOH grew at a 29.7% CAGR from 2009 to 2014.
Random information on the term “MAN”:
in the British Isles (red & grey)
The Isle of Man (/ˈmæn/; Manx: Mannin [ˈmanɪn] or Ellan Vannin [ˈɛlʲən ˈvanɪn]), also known simply as Mann, is a self-governing crown dependency in the Irish Sea between the islands of Great Britain and Ireland. The head of state is Queen Elizabeth II, who holds the title of Lord of Mann. The Lord of Mann is represented by a Lieutenant Governor. Foreign relations and defence are the responsibility of the British Government.
The island has been inhabited since before 6500 BC. Gaelic cultural influence began in the 5th century and the Manx language, a branch of the Gaelic languages, emerged. In 627, Edwin of Northumbria conquered the Isle of Man along with most of Mercia. In the 9th century, Norsemen established the Kingdom of the Isles. Magnus III, King of Norway, was also known as King of Mann and the Isles between 1099 and 1103.
In 1266, the island became part of Scotland under the Treaty of Perth, after being ruled by Norway. After a period of alternating rule by the kings of Scotland and England, the island came under the feudal lordship of the English Crown in 1399. The lordship revested into the British Crown in 1765, but the island never became part of the Kingdom of Great Britain or its successor the United Kingdom: it retained its status as an internally self-governing Crown dependency.
Random information on the term “BOY”:
Boy (stylized BOY) is a Swiss–German pop duo founded in 2007 by Swiss singer Valeska Steiner and German bassist Sonja Glass. The two met while at a pop-music course at the Hochschule für Musik und Theater Hamburg in 2005. The band initially played concerts exclusively, before being discovered and signed to Herbert Grönemeyer’s label, Grönland Records, in 2011.
Their debut album, Mutual Friends (Gold-certified in Germany), was produced by Philipp Steinke and released in the autumn of 2011. The band sings entirely in English in a style reminiscent of that of Leslie Feist.
In the UK, Mutual Friends was released by Decca in June 2012. The North American release of the album was in February 2013 on Nettwerk Records.
Boy won the Hamburg Musician Prize HANS in 2011 in the category Hamburgs Newcomer of the Year, and their album Mutual Friends won the 2012 European Border Breakers Award (EBBA).
The duo’s song “Little Numbers” was also featured in the Lufthansa Airline’s Business Class advertisement in mid-2012. In 2013 the song was at No. 4 in the Japan Hot 100.
Random information on the term “GOSH”:
Gwendoline Kirby was a nurse, and matron of Great Ormond Street Hospital.
She met Queen Elizabeth II when she made an official visit to the hospital in 1952, its centenary, formally greeted her on behalf of the hospital when she visited Princess Anne after the latter’s 1958 tonsillectomy, and met her again at the hospital’s 150th anniversary celebration, when the queen recognised her.
She appeared as a “castaway” on the BBC Radio programme Desert Island Discs on 24 December 1966.
Random information on the term “OHWOW”:
Diana Al-Hadid (born 1981) is a contemporary artist who creates sculptures, installations, panels and drawings using various media. She was born in Aleppo, Syria, in 1981 and currently lives and works in Brooklyn, New York.
Al-Hadid was born in Aleppo, Syria in 1981. At the age of five, she emigrated with her family to Canton, Ohio. Al-Hadid decided at the age of 11 that she wanted to be an artist, although she wasn’t initially sure how to pursue a career as an artist. Al-Hadid credits her immigrant background for her later success. The experience of being an immigrant in a new country helped her learn to properly navigate the grants process.
In 2003, al-Hadid received a BA in Art History and a BFA in sculpture from Kent State University in Ohio., In 2007, she received an MFA sculpture from Virginia Commonwealth University, Richmond (2005),. Later, she attended the Skowhegan School of Painting and Sculpture, Skowhegan, Maine (2007).
Diana al-Hadid’s often large-scale work is shown internationally. Her sculptures, panels, and drawings often reference “art from centuries past.” Al-Hadid also sources conceptual ideas and imagery from literature, history, anatomy, architecture, cosmology, and physics. Her work blurs the boundaries between figuration and abstraction. Al-Hadid has described her work as “impossible architecture.” Her sculptures frequently draw from a myriad of incongruous sources in order to confront mystical and scientific understandings of the world. Al-Hadid says of her work, “I am not trying to discover who I am through my work. I am exploring those things that make less sense to me, where there is something new to discover.” Despite their sheer physical presence, her monumental works are intricate and ethereal, inviting viewers to contemplate the human condition. Al-Hadid builds her sculptures in parts that can be assembled and disassembled as needed, and she explores the evolution of ideas as her work develops from beginning to end. Al-Hadid enjoys the process of creation: “That’s what occupies my mind: How do I build it?”
My name is Tim Jeffry, and I am a crossword solver and creator. I enjoy watching movies and series in my spare time, and I often play basketball with my sons. I solve the NY Times crossword daily and post the answers on my website.